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As part of lipid metabolism (anabolism and catabolism) a variety of biological intermediators are generated as second messengers (Huang and Freter, 2015), which manage multiple signaling pathways like cell growth, proliferation, differentiation, survival, apoptosis, inflammation, motility, and membrane homeostasis (Mattes, 2005

Corticosteroids may be considered for severe complications such as airway obstruction or hematologic involvement, but their routine use is discouraged due to uncertain long-term effects on host immunity and EBV-associated malignancy risk

As mentioned earlier, the accumulation of excessive Fe fuels the Fenton reaction, therefore deficiency of FXN can be considered an inducer of ferroptosis

10.3389/fncel.2015.00059 275 MuscoliC.SalveminiD.PaolinoD.IannoneM.PalmaE.CufariA.et al