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and N.F

Plates were incubated at 37 C overnight, and colonies were counted and normalized to sample weight

Clinical safety studies involving approximately 900 participants showed no clinically significant hormonal changes with AOD-9604, consistent with its peripheral, fat-tissue-specific mechanism of action

NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict