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However, it was found effective in countering oxidative stress in a transgenic mouse model of amyloidosis when administered from four months of age [166]

To further validate the hypothesis that Quercetin-preconditioned MSC-derived exosomes (Que-Exo) synergistically enhance chondroprotection and exert anti-inflammatory effects, we performed Western blot analysis to assess the expression of inflammatory markers (iNOS, TNF-) and catabolic enzymes (MMP-3, MMP-13) in IL-1-stimulated chondrocytes

Among them, PMM catalyzes the conversion of mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P) (Zhang et al., 2018)

Outcome measures include biomechanical testing (load to failure, stiffness), histological scoring (collagen organization, fibroblast density), and functional assessment (gait analysis, range of motion)