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Our structures clearly reveal the ligand-binding pocket for ghrelin, where the peptide moiety of ghrelin mainly occupies cavity I while the octanoyl moiety adopts an extended conformation to occupy cavity II

(CAL) and Adina pilulifera (AP), is commonly used as a therapy for H

et al., 2021), which in turn may cause or aggravate several features possibly relevant to ME/CFS, including production of reactive oxygen species (ROS) (Padro and Sanders, 2014