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Indeed, GSTM1 has a similar function as GSTM2 , but several single-nucleotide polymorphisms may lead to gene inactivation

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However, during inflammation, these processes are impaired, and lipoprotein oxidation is intense and allows for their accumulation in the subendothelial space

HS- 173 selectively activates RIP3 and MLKL, inducing necroptosis in RIP3-expressing NSCLC cells and suppressing tumor growth in mouse models (Park et al