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In parallel, the animal study by Feng et al

629 Transdermal buprenorphine, when tolerated, is an effective therapy for PDPN

2.3.4 Other nanoparticles that reprogram TAMs In addition to TLR agonists and signaling pathway inhibitors or activators, there are various other nanoparticles that have been shown to exert anti-tumor effects by targeting TAMs and reprogramming M2 TAMs into M1 TAMs