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Only the Lipoic acid ((R)-(+)--Lipoic acid) exists in nature and is an essential cofactor of four mitochondrial enzyme complexes

[PubMed] Bennett, T.M., D.S

68 However, the subsequent degranulation reaction (lasting for 24 h) was HIF-1-dependent, manifested by an increase in the expression of the MMP-8 gene in the promoter region that contains HREs