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(C) Acquired resistance mechanisms: Acquired resistance is mediated by secondary mutations in the target protein, activation of alternative pathways through other receptors or downstream proteins, or phenotypic transformation

J Neuroinflammation 11:112 Vernon SD, Unger ER, Dimulescu IM et al (2002) Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome

This neurovascular coupling could be elucidated by monitoring the dynamic changes of the regional cerebral arterial blood flow

Although habitual napping has been correlated with negative cognitive and physical health outcomes, especially in older individuals, occasional short naps in the early afternoon may improve mental and emotional function without disrupting the sleep-wake cycle