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1 Introduction Pain is a protective response necessary for species survival and a global health problem affecting human life, health, and social development ( Ferroptosis, a unique form of oxidation and iron-driven programmed cell death, has been demonstrated to participate in various types of pain ( Over the past few years, numerous studies on the correlation between pain and ferroptosis have exploded, making the mechanisms involved increasingly clear

for review Han et al., 2019

they conclude that the differences in metabolism are due to immature glucuronidation and that sulphation is the major route of excretion [49]