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One such example comes from a longitudinal study of patients with metastatic CRC in which genetic data were consistent with parallel selection during metastasis evolution dependent on the strength and quality of the local immune response: metastatic clones could be traced back to immune-privileged clones that were capable of escaping the intrametastatic immune microenvironment, while the eliminated clones were immunoedited

Leibelt DA, Hedstrom OR, Fischer KA, Pereira CB, Williams DE

NFTs, on the other hand, arise from the hyperphosphorylation of tau, a microtubuleassociated protein that stabilizes neuronal cytoskeletons

Adipose tissue collagen vi in obesity