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In addition, increasing TFAM levels enhanced mitochondrial DNA transcription and replication, aiding in the recovery of mitochondrial function, while boosting GPX4 levels directly reduced LPO buildup, thereby preventing ferroptosis

10.3390/nu8070426 190 MaY.ChapmanJ.LevineM.PolireddyK.DriskoJ.ChenQ

Since mutant ChaC1-knock-in mice have been examined only in limited situations, it remains ambiguous whether a deficiency of CHAC 1 activity affects phenotypic properties under pathological conditions such as ER stress, oxidative stress, and ferroptosis

37 , 38 , 39 Partial indirect support for this is that G6PD deficiency in Sardinia is more common at sea level compared to higher elevations, and this also parallels the endemicity of malaria