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This accumulation of oxidative damage is one of the central drivers of what researchers call biological aging

Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with copd exacerbations: results of a double blind, placebo-controlled trial

Carty J, Navarro VJ

KEAP1-NRF2 system as a potential therapeutic target in ALS The presence in ALS of increased levels of OS markers and impaired antioxidant defense in the brain and peripheral tissues [25] together with the central role of NRF2 in inducing target genes to counteract OS [272] make the KEAP1-NRF2 system a suitable therapeutic target for drugs and small molecules