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and melatonin exerts pleiotropic effects on mitochondrial function, circadian regulation, and redox balance

Interestingly, chronic supplementation with fucoidan mitigated the downregulation of BDNF-dependent synaptic plasticity by reducing caspase-1-mediated inflammation and substantially improving behavioral deficits associated with caspase-1 overexpression in the hippocampus of mice

This feature is generally advantageous for avoiding central nervous system-related side effects 165,166

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