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The main symptoms to note are constantly feeling sluggish, weakness, trouble losing weight, numbness, along with other signs

doi: 10.1248/bpb.b22-00839 30 IsikS.Yeman KiyakB.AkbayirR.SeyhaliR.ArpaciT

270 More importantly, p53 is regulated only in AgRP neurons and not in major neuronal populations of the arcuate nucleus of the hypothalamus (ARC), which suggests that p53 alterations associated with energy balance are nucleus-specific

Symptoms of Mn deficiency include short stature, cognitive impairments, developmental delays, cerebellar atrophy, and hypotonia, often appearing at birth or in early childhood (Riley et al., 2017