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Vaughn DJ, Bellmunt J, and Fradet Y, et al (2018) Health-related quality-of-life analysis from KEYNOTE-045: a phase III study of pembrolizumab versus chemotherapy for previously treated advanced urothelial cancer J Clin Oncol 36 (16) 15791587 PMID: 29590008 10

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Also, a substantial decrease in glutathione levels precedes the mitochondrial dysfunction and neuronal death found in Parkinsons disease, suggesting GSH depletion may initiate the subsequent impairment.It also suggests that increasing GSH levels may have potential benefit toward preventing diseases associated with mitochondrial dysfunction