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The fourth stage causes severe problems like nerve damage and memory loss

However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets

Atrial fibrillation (AF) is the most frequently occurring sustained cardiac arrhythmia and is linked to heightened morbidity and mortality rates, in addition to increased healthcare costs (2)(3)