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Explanations: beta-2 agonists produce bronchodilation, but are not anti-inflammatory fomorterol has a rapid onset very similar to SABAs (within 5 minutes), but has the additional benefit of a ~ 3 fold longer (12 vs 4 hour) duration of action ICS reduces inflammation, which is the major cause for worsening of asthma Step Down Therapy When patients with asthma have symptoms that are well-controlled by a stable drug regimen for 3 to 6 months, it is recommended that controller medications be reduced in a step-wise manner to minimize potential adverse effects (especially corticosteroids), as well as expense and inconvenience

Therefore, customized dosages of biological agents for pSS treatment are worthy of further investigation

Abstract Neuropathic pain (NP), affecting 710% of the general population, results from damage to the somatosensory nervous system and leads to persistent discomfort, functional limitations, and psychological distress

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