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Only a handful of small studies have been completed, with inconclusive results

Lactate shuttling links histone Kla, particularly H4K12la, to neural stem cells (NSCs) proliferation through murine double minute 2 (MDM2)-p53 signaling pathway and eventually regulates cell cycle and endows NSCs neurogenic potential in the adult hippocampus

These forms of restrictive progression have been manifested in various cancer cells, including brain, colorectal, hepatic, lungs, ovarian, skin, pancreatic, and renal cancer tissues, amongst others