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For example, PHGDH is overexpressed in glioma and stabilises the transcription factor, FOXM1, leading to increased expression in genes that promote tumour invasion, angiogenesis, and regulate the cell cycle (Liu et al, 2013)

However, several limitations may preclude the use of Fer-1 and Lip-1 in clinical settings, including their possible unsatisfactory pharmacokinetics and pharmacodynamics profiles