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Systemic regulation of iron metabolism primarily occurs in the liver, where hepcidin binds to FPN, leading to its degradation and inhibition of iron export, thereby contributing to intracellular iron accumulation [99]

Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, et al

In further support of this finding, the drug induced expression of several oxidative stress pathway proteins, including nuclear factor (erythroid-derived 2)-like 2 (NRF2), a master regulator of the antioxidant response and haem oxygenase 1 (HMOX1), encoded by the NRF2 target gene HMOX1 (Fig

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