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[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Yim W, Zhou J, Mantri Y, Creyer MN, Moore CA and Jokerst JV, ACS Appl

For example, PTEN mutations, which occur downstream of EGFR signaling, have been identified as a resistance factor in anti-EGFR therapy for GB, highlighting the complexity of these pathways and the challenges in developing effective targeted treatments ( Figure 1 further illustrates the intricate and overlapping signaling cascades within the RTK pathway, emphasizing the complexity involved in the context of the various targeted therapeutics discussed above

GFP fluorescence levels were significantly increased in worms fed mutant diets compared to the control diet, indicating UPRmt activation (Fig

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