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Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid