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J Pineal Res 66(2):e12548 Mistraletti G, Umbrello M, Sabbatini G, Miori S, Taverna M, Cerri B, Mantovani ES, Formenti P et al (2015) Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial

65-year-old patient Enalapril + Furosemide Diclofenac added for pain Within days: Urine output dropped Creatinine spiked Diagnosis: This is the ACE inhibitor + Diuretic + NSAID Individually

- Cng thc ci tin gip h tr kh mi ln ti 48h, v khng gy vt vng trn o - H tr se kht l chn lng, gip da mm mn, m vt thm khng gy kch ng v khng lm nh hng n mi nc hoa bn dng

Synergistic Effects Synergistic effects refer to when two or more agents act together to generate an activity greater than the sum of their individual activities