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Also in this case, the preferential functionalization of CDs involves the use of biomolecules, such as amino acids and aptamers, to achieve promising results toward a preclinical AD application: for example, a Korean research team (Chung et al., 2020) has decorated carbon dots with aptamers to selectively targeting A 42 species whereby highlighting their therapeutic functions

Cytosolic escape of mitochondrial DNA triggers cGAS-STING pathway-dependent neuronal PANoptosis in response to intermittent hypoxia

These studies were supported, in whole or in part, by NIH grants R01 HL149825 to ALM and ACS and HL145550 to ALM and MR

In addition, ADCs can also exert an extracellular action on neighbouring cells via the release of the payload after intracellular cleavage of the linker (bystander effect), which is mediated by the proteases localised in lysosomes