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Crosstalk Between Oxidative Stress, Autophagy and Cell Death Pathogenesis of Autoimmune Disease IntechOpen Frontiers The role of TIGAR in nervous system diseases Autophagy: Regulator of cell death Cell Death & Disease Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation.

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