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High levels of S100A9-positive macrophages in tumors have been correlated with poor patient outcomes in conditions like head and neck cancer and metastatic melanoma, indicating its association with reduced survival rates and diminished response to anti-PD-1 immunotherapy [148]

Indian J Endocrinol Metab 16:S2736 Cham CM, Driessens G, OKeefe JP, Gajewski TF (2008) Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells