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Abbreviations CNS Central nervous system BDNF brain-derived neurotrophic factor CSF cerebrospinal fluid AD Alzheimers disease D H dopamine -hydroxylase A amyloid- APP amyloid precursor protein AA ascorbic acid AGEs advanced glycation end products RAGE receptors for AGE BBB blood brain barrier LRP-1 low-density lipoprotein receptor-1 GSH glutathione SSRIs selective serotonin reuptake inhibitors 4-HNE 4-hydroxynonenal MCI mild cognitive impairment ROS reactive oxygen species CDR Clinical Dementia Rating HPA hypothalamicpituitaryadrenal MMSE Mini-Mental State Examination CI confidence interval IQR inter-quartile range SMD standard mean deviation

XZ: Formal analysis, Writing review & editing, Writing original draft

6 min, 20% B

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