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Notably, melatonin has been reported to ameliorate oxidative stress and mitochondrial damage caused by cadmium (Cd) exposure in the plant, fish, and rat models 8,9,10,11,12,13

A combination of radiotherapy with TMZ might be a preferred treatment option in aggressive PRLomas, as it shows better tumour control than either TMZ or radiotherapy alone (236)

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The clinical trial protocol starts at 0.25 mg to 0.3 mg weekly and increases every 4 weeks through escalation steps of 0.6 mg, 1.2 mg, 1.8 mg, and finally 2.4 mg