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Some animal studies indicate BPC-157 may positively influence insulin sensitivity and glucose metabolism, both crucial for maintaining a healthy weight and preventing fat accumulation

For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies

Rather, a growing body of evidence suggests that the systemic and local actions of incretins and metabolic hormones modulate multiple pathways that can promote inflammatory and fibrotic injury

[DOI] [PMC free article] [PubMed] [Google Scholar] Marcus A.J., Iezhitsa I., Agarwal R., Vassiliev P., Spasov A., Zhukovskaya O., Anisimova V., Ismail N.M