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During states of increased systemic inflammation, such as sepsis or trauma, the brain experiences a mismatch between energy supply and demand, which is commonly associated with delirium in those with preexisting cognitive impairment [3]

In addition, some ASCT2 inhibitors can also block other amino acid transporters (SLC7A5, SLC38A2) (Tang et al., 2022

Br J Pharmacol 150:517 Sheldon AL, Robinson MB (2007) The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

A summary of suggested mechanisms of action of environmental chemicals on DNA methylation machinery is shown in Figure 1