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By explicitly mapping these relationships, the review underscores how discrete metabolic pathways in CSCs and immune subsets converge to shape ICI resistance, and how metabolic interventions offer rational strategies to restore therapeutic efficacy

Specifically, the enzymatic activity of glutathione synthetases decreased slightly at earlier time points, but increased slightly at later time points

Heightened anxiety-like phenotypes are consistent with prior work linking prenatal THC and gestational stress to altered HPA axis function and emotional circuit maturation [50, 51, 52, 53], although HPA activity was not directly assessed here

Gut 70 , 157169 (2021)