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For example, sulforaphane attenuated cell necrosis and apoptosis in renal injury rats 51 and type 1 diabetes mice 52 models

The prediction of future conversion to MCI over 15 years is unlikely to be explained by undiagnosed cognitive impairment, placing changes detected by these aging models early in the causal chain of cognitive decline and neurodegenerative disease

They also recommended expanding genotyping panels to include other relevant pharmacokinetic and pharmacodynamic genes beyond CYP2D6 and CYP2C19 , thereby capturing the full scope of genetic determinants influencing antidepressant response

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