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This transition enables VSMCs to proliferate, migrate, secrete extracellular matrix components and inflammatory factors, thereby driving neointima formation and vascular remodeling ( 2.4.1 Molecular regulatory mechanisms of phenotypic switching The phenotypic switching of VSMCs is precisely regulated by various factors and signaling pathways

To measure metabolites, the culture was centrifuged at 20,000 g for 3 min to remove bacterial cells, and the metabolites in the supernatant were assayed using the L-glutamate kit Yamasa NEO (Yamasa Corporation, Chiba, Japan) and F-kit (D-glucose) (Roche/R-Biopharm, Darmstadt, Germany) in accordance with kit instructions

For dietary deficiency without neurological involvement, oral supplementation may be appropriate

Nevertheless, they may eventually experience disease progression, indicating development of resistance to anti-CD38 antibody therapy