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Although the [U- 13 C]glucose isotope-labeling assay showed slightly increased incorporation of [ 13 C]glucose-derived carbons into glutamate (Figure 3A), -ketoglutarate (-KG) (Figure 3C), and GSH (Figure 3E) as well as GSSG (Figure 3G), the relative levels of overall glutamate (Figure 3B), -KG (Figure 3D), and GSH (Figure 3F) among all detected metabolites decreased

In the absence of reduced glutathione (e.g., due to G6PD deficiency), RBCs become susceptible to oxidative stress that can damage erythrocyte membranes, resulting in intravascular and extravascular hemolysis

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The investigations on in vitro BBB or BCB models, analogous to those published by Mller et al