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Bones grow in length by endochondral ossification in cartilaginous growth plates at ends of developing long bones

ACS Chem Neurosci 9(5):873885

On the other hand, GPx5, GPx7, and GPx8 contain cysteine in their active site [1, 8, 9]

While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension (Gerhardsson, 2022)