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Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors

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10.3390/ijms17071166 45 JonesS

Peptides with sequences rich in hydrophobic residues, or those with a high proportion of basic amino acids (lysine, arginine, histidine) that require protonation for charge-mediated aqueous solubilisation, typically reconstitute cleanly and completely in 0.1% acetic acid water whereas the same peptides may form aggregates, gels, or turbid suspensions when reconstitution with neutral sterile water or bacteriostatic water is attempted first