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This deficiency can also cause various symptoms, including fatigue, head and neck tension, poor mental health, pale or yellow skin, mental impairment, and pain and swelling in the mouth and tongue

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Occasionally, an advisory committee (AdCom) meeting is convened to assess the drug or device under consideration

Depending on which nerves are affected, it can cause numbness, tingling, burning pain, weakness, or problems with automatic body functions like blood pressure, digestion, or bladder control