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These symptoms can indirectly affect body weight because low energy often reduces appetite and activity

Patients who took a high dose of tirzepatide lost 22.5% of their body weight on average, or 52 pounds, better than any medication currently on the market

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These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19