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Studies have demonstrated that vitamin E supplementation reduces oxidative stress markers in ovarian tissue, preserving mitochondrial function and energy availability within oocytes, ultimately enhancing their viability and developmental potential [52,53,54,55,56]

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The phagocytic capacity of macrophages toward ferroptotic tumor cells demonstrates anti-tumor activity, with various immune-stimulatory signals released by ferroptotic tumor cells enhancing phagocytic efficiency ( 6 Iron metabolisms influence on macrophage polarization Macrophages store iron through FT binding, with iron-related gene expression profiles varying across polarization stages

It has been investigated that TMAO reduces the expression of CYP7A1 and CYP27A1, two key enzymes necessary for the synthesis of BAs, and various BA transport proteins, decreases BA biosynthesis, inhibits the reverse cholesterol transport (RCT) pathway, and affects BA metabolism and cholesterol homeostasis in the hepatic-intestinal tract (Wang et al., 2011)