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Characterized Signaling Pathways Published research has identified multiple receptor-mediated signaling interactions: MC1R / cAMPPKAMITF Axis MT-1 binds with high affinity to the melanocortin 1 receptor (MC1R), activating Gs-coupled adenylyl cyclase and elevating intracellular cAMP

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Although acquired melanocytic naevi are the most common benign skin lesion in people under 40 years of age, seborrhoeic keratoses become more common later in life (Figure 3)