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182,193 Potential adverse side effects of estrogen therapy include breast tenderness, bloating, nausea, headaches, leg cramps, and vaginal or breakthrough bleeding

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Additional studies have linked SLC25A39 to metal homeostasis and neuronal injury, and identified it as a genetic risk factor for Parkinsons disease 19 Moreover, SLC25A39 has been shown to play a crucial role in mitochondrial heme biosynthesis, with its silencing impairing iron incorporation into protoporphyrin IX in murine erythroleukemia cells 20,21

Moreover, NRF2 target genes are also critical mediators to enhance the metabolism of pro-tumorigenic xenobiotics