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Besides interacting with ECS receptors, cannabinoids affect also non-ECS receptor targets, such as the serotonin receptor 5-HT1A, the non-selective TRPV1 cation channel with preference for calcium ions [47], and PPARs, explaining their broad physiological effects [48]

The present study demonstrated that, although GSH levels are continuously increased following OXA withdrawal and liver MDA levels are continuously increased, GSH-Px and SOD levels are consistently decreased and are accompanied by elevated ALT and AST levels

Glutathione is a small compound made inside the body that helps protect cells from oxidative wear

Sims et al., 2023)