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[21] Furthermore, an animal study in ewes demonstrated that a B 12 , folate and methionine restricted diet around conception, resulted in offspring with higher adiposity, blood pressure and insulin resistance which could be accounted for by altered DNA methylation patterns

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Males and females were treated with 20 mM BSO (19176, Sigma-Aldrich) in the drinking water starting at 21 days of age, immediately after weaning

4 Discussion The present systematic review underscores the potential role of VR-based interventions in individuals experiencing cognitive decline (Figure 4)