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Highlighting the key role testosterone plays as a primary anabolic hormone in muscle adaptation following exercise training, through its interaction with anabolic signaling pathways and other hormones via the androgen receptor (AR), this review also describes the potential importance of fluctuations in other hormones such as GH and IGF-1 in concert with dietary amino acid availability

Notably, elevated adiposity further reduces serum IGF-I concentrations independent of chronological age

Sen T, Gay CM, Byers LA