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Other compounds Cyanidin-3-O--glucoside (C3G) increases the expression of Gclc in the liver by increasing cAMP levels to activate protein kinase A (PKA) and then increases the phosphorylation of cAMP response element binding protein (CREB) to promote CREB-DNA binding and increase Gclc transcription

However, in local tissues, steroid metabolic reprogramming is driven by pro-inflammatory factors such as TNF-: inflammatory cytokines induce the overexpression of aromatase (Aromatase/CYP19A1), accelerating the conversion of the substrate testosterone into estradiol and leading to an excessive local production of E2 (154, 155)

The Arabidopsis Book, pp e0131 Dixon DP, Edwards R (2010b) Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing