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4.5 Copper Copper (Cu) plays two main roles: it promotes melanogenesis and provides physiological protection against oxidative stress by participating in the destruction of free radicals through the formation of superoxide dismutase, which catalyses the dismutation of reactive oxygen species to oxygen (O 2 ) or H 2 O 2

Melatonin is derived from serotonin, a neurotransmitter that originates from the amino acid tryptophan

Radiation necrosis (RN) may occur from months to years following treatment, affecting a reported 324% of patients [13]