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Description

Xia Ye, Zhang H, Wang Z, et al

10.1126/science.1088172 20 GongF.YangN.WangY.ZhuoM.ZhaoQ.WangS.et al (2020)

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However, the clinical development of some ultra-potent DNA-intercalators like the pyrrolobenzodiazepine (PBD) dimers has been challenged by significant off-target toxicities, potentially related to their persistent DNA damage and the bystander effect [47]