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Animal models of asthma have indicated that the expression of the clock gene BMAL1 plays a role in eosinophil trafficking and the production of the cytokine IL-5 [23], which is a target of multiple asthma drugs and has been shown to be under epigenetic regulation [24]

Another neuronal-targeting peptide, Ten Eleven Translocation one (Tet-1), derived from tetanus toxin, binds to tri-sialo-ganglioside receptors located on the surface of motor neurons and has been used successfully to deliver therapeutic agents to neurons in several models (87)

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A rare case involved a woman who had immediate adverse reactions to both cyanocobalamin and hydroxocobalamin, by both injection and oral delivery