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Furthermore, VIT-E directly diminishes the expression of 12/15-LOX, an enzyme responsible for metabolizing linoleic acid and AA into HODE and HETE, respectively [92]

doi: 10.1038/nrc3431 95 BanningAKippASchmitmeierSLwingerMFlorianSKrehlSet al

SF (28.2 mol/kg an hour after SCI induction) activation of Nrf2 post-SCI improved locomotor function and reduced inflammatory damage, neuron death, and spinal cord edema, while neurological deficits were more severe and the protective effect of SF was not observed in Nrf2 deficient mice (105)