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Specifically, hypoxia upregulates HIF-2 in PAECs, leading to enhanced expression of the p53 protein, which subsequently increases the levels of cleaved Caspase-3 and promotes apoptosis

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Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial